Bukayo Saka keeps his place in the starting line-up but there is debate as to whether his role will be more as a left wing-back or as a central midfielder in a 4-3-3.
In goal is Bernd Leno, while the defence is made up of Hector Bellerin at right-back with David Luiz and Gabriel Magalhaes as the centre-backs and Kieran Tierney at left-back. If it is a back three, however, Tierney will take more of a centre-back role.
One of the most surprised calls from Arteta is that Granit Xhaka has been dropped from the midfield. Dani Ceballos and Mohamed Elneny start in his place but will find assistance on the left from Saka when needed.
There has also been a shock in the front three as Eddie Nketiah starts over Alexandre Lacazette. The Frenchman had started all three previous Premier League games and scored in each but finds himself on the bench this afternoon.
Willian keeps his place on the right wing, where he will drift infield as Pierre-Emerick Aubameyang will do from the left wing.
The bench is: Runar Alex Runarsson, Lacazette, Ainsley Maitland-Niles, Rob Holding, Nicolas Pepe, Joe Willock and Xhaka.
Here is what Arsenal fans have had to say on the lineup:
After three straight away games, the Gunners return to Emirates Stadium looking to build on their strong home form to create a platform for success in 2020/21.
Unbeaten in their last 10 home league games, Arteta is hoping Arsenal can take that momentum into this afternoon’s match and beyond the international break.
“I think we can create, the Emirates, a furnace for us. I think it’s going to be crucial for the future at the end of the season,” he said in his pre-match press conference.
“Not just the results but as well the performance, where we can inspire and transmit that form and play with that confidence at home that we have to be really resilient and dominate games and impose ourselves in those games.
“I think the game on Sunday is a really difficult one. I watched the Sheffield [United] games already any they merit much more from those games. The way they played is tricky so I’m expecting a very difficult game.”
While a win will be the expectation for Arteta this afternoon, he has first-hand experience of just how tough facing Sheffield United can be. Last season, the Blades took four points off Arsenal in the Premier League and it wasn’t until the dying minutes at Bramall Lane that Dani Ceballos secured a 2-1 win in the FA Cup quarter-final.
The Blades are still searching for their first win of the season but the Arsenal boss knows the challenge he is facing going up against Chris Wilder again.
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“The margins between winning, drawing and losing are really small but they have generated big chances in every game and have been really unlucky in my opinion not to get anything out of those games,” he added.
“We have experience of playing them both in the Premier League and the cup and we know how difficult it is to play against them.
“The season they had, the way they have evolved the team since they’ve joined the Premier League has been unbelievable, what their manager has done with the coaching staff, with the resources they have, I think it’s remarkable. So we need to be really alert and have to play at our best again.”